Broncos vs 49ers Prediction
Sunday, Oct 4, 2026, 4:25 PM ET, Levi's Stadium, Santa Clara, Week 4
Agatha Research Desk, Updated
AGATHA'S PICK
AWAYDenverBroncosAGATHA'S PICK
HOMESan Francisco49ers
AWAYDenverBroncosPREDICTED SCOREPREDICTED SETSMATCHUPLIVEDELAYEDFINALPOSTPONEDLIVE
1424vs
Predicted --
HOMESan Francisco49ers62%WIN CHANCELIVE READ49ers to WinWON#288 SEALEDSEALED ODDS -Agatha's pick: 49ers to WinTHE VERDICT
Win chance at the seal 62%
Final score: 49ers 24, Broncos 14
- SEALED ODDS
- -152Unibet
- CLOSING ODDS
- -156Unibet, at the start
- STAKE
- 1 unitflat, every pick
- RESULT
- WON +0.66uat the sealed price
- GRADED
- 7:39 PM ETreceipt #288
Game Center
| Team | 1 | 2 | 3 | 4 | T |
|---|---|---|---|---|---|
| DEN | 3 | 0 | 0 | 11 | 14 |
| SF | 0 | 3 | 7 | 14 | 24 |
Play-by-play
- [4- 2:00] (Shotgun) B.Nix pass incomplete short right to E.Engram.
- [4- 2:00] Two-Minute Warning
- [4- 2:07] (Shotgun) B.Nix pass short left to T.Badie to DEN 49 for 7 yards (R.Green). ** Injury Update: SF-U.Stout has returned to the game.
- [4- 2:07] Official Timeout at 02:07.
- [4- 2:15] E.Pineiro kicks 60 yards from SF 35 to DEN 5. R.Harvey MUFFS catch, and recovers at DEN 5. R.Harvey to DEN 42 for 37 yards (L.Gifford). SF-M.Sigle was injured during the play.
Leaders
- Brock Purdy (SF): 19/30, 218 YDS, 2 TD
- Christian McCaffrey (SF): 15 CAR, 52 YDS, 1 TD
- Mike Evans (SF): 5 REC, 76 YDS
- Bo Nix (DEN): 25/42, 214 YDS, 1 TD
- J.K. Dobbins (DEN): 11 CAR, 40 YDS
- RJ Harvey (DEN): 10 REC, 68 YDS
Game-day injuries
- Upton Stout (SF) - Questionable
- Kyle Juszczyk (SF) - Out
- Jordan James (SF) - Out
- James Thompson Jr. (SF) - Out
- Ephesians Prysock (SF) - Out
- Pat Bryant (DEN) - Questionable
- Riley Moss (DEN) - Out
- Pat Surtain II (DEN) - Out
- Dallen Bentley (DEN) - Out
- Dondrea Tillman (DEN) - Out
DENTale of the tape
SFBroncos vs 49ers recent form
DEN 3-2 Broncos: last 5 games
- W30-26LAR Sep 27 Los Angeles Rams, 30-26
- W20-13JAX Sep 20 Jacksonville Jaguars, 20-13
- L10-31KC Sep 14 Kansas City Chiefs, 10-31
- L7-10NE Jan 25 New England Patriots, 7-10
- W33-30BUF Jan 17 Buffalo Bills, 33-30
SF 4-1 49ers: last 5 games
- W36-30ARI Sep 27 Arizona Cardinals, 36-30
- W35-13MIA Sep 20 Miami Dolphins, 35-13
- W27-7LAR Sep 10 Los Angeles Rams, 27-7
- L6-41SEA Jan 17 Seattle Seahawks, 6-41
- W23-19PHI Jan 11 Philadelphia Eagles, 23-19
Points scored, last 5DEN 100SF 127
Points allowed, last 5fewer is betterDEN 110SF 110
Broncos vs 49ers line movement
Market (latest pregame line)
Spread (SF)
-3
Total
48.5
Moneyline
- DEN
- +142
- SF
- -165
Line movement, tracked by Agatha since first sighting (18 snapshots)
- Moneyline (SF) at FanDuel: opened -205, now -156
- Spread (SF) at FanDuel: opened -3.5, now -2.5
- Total at FanDuel: opened 46.5, now 48.5
Agatha's pick for Broncos vs 49ers
The 49ers. Agatha gave San Francisco a 62% chance to win at Levi's Stadium, Santa Clara. It was one of Agatha's Best NFL Bets for Oct 4.
TV: CBS