A 38-13 win
Guerendo had 78 rushing yards, 2 rushing touchdowns and 2 catches for 50 receiving yards on Dec 8, 2024, in a 38-13 win against the Chicago Bears.
FootballNFLSan Francisco 49ersRunning back
Isaac Guerendo
Stats, career, game log and next gameIsaac Guerendo is a running back for the San Francisco 49ers who was drafted in the 4th round of the 2024 NFL Draft.
30 NFL games2 seasons
Updated
About Isaac Guerendo
Isaac Guerendo is a running back for the San Francisco 49ers and wears number 31. Born on June 28, 2000, in Clayton, Indiana, United States, he played college football at Wisconsin and Louisville. Guerendo was drafted in the 4th round of the 2024 NFL Draft, with the 129th pick overall, and has played for the San Francisco 49ers since 2024. In the 2024 regular season he had 420 rushing yards, 4 rushing touchdowns and 15 catches for 152 receiving yards.
Agatha Research DeskUpdated Oct 6, 2026Season by season30
Every season, every NFL game in our records, newest season first.
| Season | Team | Games | Carries | Rush yds | Rush TD | Catches | Rec yds |
|---|---|---|---|---|---|---|---|
| 2025 | SF | 14 | 0 | 0 | 0 | 0 | 0 |
| 2024 | SF | 16 | 84 | 420 | 4 | 15 | 152 |
| Career | 30 | 84 | 420 | 4 | 15 | 152 |
How he is doing now
49ers4-02026 regular season
Last gamePlayedno stats recorded, Dec 14 vs Titans
Injury status
No injury reports on file.
Next game
San Francisco 49ers at Seattle Seahawks - 4:25 PM ETAgatha predicts SF 20, SEA 2563%PRED1U
Guerendo against the Seahawks3 games, 10 carries, 99 yds
Last met Sep 7, 2025; his teams 2-1.
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Career
San Francisco 49ers2024 to now - 30 games2years2024 to 2025
- 2024NFL debut32-19 win vs Jets
- 2024Best game15-78, vs Bears
- 2024Best season420 rushing yds, 4 TD, 15 catches in 16 games
- Dec 14, 2025Latest gamevs Titans
Regular season
30 games
420 rushing yds, 4 TD, 15 catches
First NFL game
Sep 9, 2024: 0 rushing yds, 0 TD49ers 32, Jets 19
Latest game
Dec 14, 2025: no stats recorded49ers 37, Titans 24
Most often against
The teams he has faced most, with his teams' record and his line against each.
Arizona Cardinals4 games
2-2his teams
His line: 7 carries, 27 yds
Last met Nov 16, 2025
Los Angeles Rams4 games
1-3his teams
His line: 4 catches, 18 yds
Last met Nov 9, 2025
Seattle Seahawks3 games
2-1his teams
His line: 10 carries, 99 yds
Last met Sep 7, 2025
Tampa Bay Buccaneers2 games
1-1his teams
His line: 1 carry, 0 yds
Last met Oct 12, 2025
Atlanta Falcons1 game
1-0his teams
Last met Oct 19, 2025
Buffalo Bills1 game
0-1his teams
His line: 1 catch for -3 receiving yards
Last met Dec 1, 2024
Sources and updates
Stats, scores and injury reports come from Agatha's own records: nflverse weekly stats, ESPN box scores and ESPN's injury reports.
Updated Oct 6, 2026, 1:23 PM ET. Results and form refresh after every game; biography facts are checked weekly.