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Lions vs Cardinals Prediction

Sunday, Oct 11, 2026, 4:25 PM ET, State Farm Stadium, Glendale, Week 5

Agatha Research Desk, Updated

AGATHA'S PICKDetroit LionsAWAYDetroitLions

FINAL

4521

Arizona CardinalsHOMEArizonaCardinals
66%WIN CHANCELions to WinWON#817 SEALED

Win chance at the seal 66%

Agatha's pick: Lions to WinTHE VERDICT

Final score: Lions 45, Cardinals 21

SEALED ODDS
-237Pinnacle
CLOSING ODDS
-238Pinnacle, at the start
STAKE
1 unitflat, every pick
RESULT
WON +0.42uat the sealed price
GRADED
7:30 PM ETreceipt #817

Game Center

Team1234T
DET02414745
ARI707721

Play-by-play

  • [4- 2:23] Timeout #1 by DET at 02:23.
  • [4- 2:27] (Shotgun) J.Brissett pass incomplete short left to R.Virgil.
  • [4- 2:31] (No Huddle, Shotgun) J.Brissett pass incomplete short left to K.Bourne (A.McNeill).
  • [4- 2:38] (No Huddle, Shotgun) J.Brissett scrambles left end ran ob at DET 9 for 18 yards (C.Clark).
  • [4- 2:45] (No Huddle, Shotgun) J.Brissett pass short left to K.Bourne pushed ob at DET 27 for 8 yards (R.McCreary).
  • [4- 3:11] (No Huddle, Shotgun) J.Brissett pass short middle to R.Virgil to DET 35 for 16 yards (K.Abney).
  • [4- 3:33] (Shotgun) J.Brissett pass short left to J.Brooks to ARZ 49 for 7 yards (D.Moore; E.Rakestraw).
  • [4- 3:38] (No Huddle, Shotgun) J.Brissett pass incomplete deep left to R.Virgil.
  • [4- 4:00] (No Huddle, Shotgun) J.Brissett pass short right to T.Allgeier to ARZ 42 for 4 yards (J.Campbell).
  • [4- 4:25] (Shotgun) J.Brissett pass short left to R.Virgil to ARZ 38 for 13 yards (E.Rakestraw).
  • [4- 4:51] (Shotgun) J.Brissett pass short right to T.McBride to ARZ 25 for 3 yards (J.Mills).
  • [4- 4:55] (Shotgun) J.Brissett pass incomplete short middle to K.Bourne.

Leaders

  • Jacoby Brissett (ARI): 29/47, 292 YDS, 3 TD, 1 INT
  • Jeremiyah Love (ARI): 12 CAR, 22 YDS
  • Kendrick Bourne (ARI): 5 REC, 70 YDS
  • Jared Goff (DET): 19/30, 271 YDS, 3 TD
  • Jahmyr Gibbs (DET): 25 CAR, 151 YDS, 2 TD
  • Sam LaPorta (DET): 5 REC, 88 YDS, 1 TD

Game-day injuries

  • Wydett Williams Jr. (ARI) - Questionable
  • Carson Beck (ARI) - Out
  • Starling Thomas V (ARI) - Out
  • Andrew Wingard (ARI) - Out
  • Andrew Billings (ARI) - Out
  • Devin White (DET) - Questionable
  • Tom Kennedy (DET) - Questionable
  • Jackson Meeks (DET) - Out
  • Mekhi Wingo (DET) - Out
  • Rock Ya-Sin (DET) - Out
DET

Tale of the tape

ARI

Lions vs Cardinals recent form

DET 3-2 Lions: last 5 games

  1. L26-32CAR Oct 4 Carolina Panthers, 26-32
  2. W31-24NYJ Sep 27 New York Jets, 31-24
  3. L31-41BUF Sep 17 Buffalo Bills, 31-41
  4. W31-30NO Sep 13 New Orleans Saints, 31-30
  5. W19-16CHI Jan 4 Chicago Bears, 19-16

ARI 1-4 Cardinals: last 5 games

  1. L24-36NYG Oct 4 New York Giants, 24-36
  2. L30-36SF Sep 27 San Francisco 49ers, 30-36
  3. L7-31SEA Sep 20 Seattle Seahawks, 7-31
  4. W26-14LAC Sep 13 Los Angeles Chargers, 26-14
  5. L20-37LAR Jan 4 Los Angeles Rams, 20-37
Points scored, last 5DET 138ARI 107
Points allowed, last 5fewer is betterDET 143ARI 154

Lions vs Cardinals head-to-head

Since Sep 22, 2024: Lions 1, Cardinals 0

  1. Sep 22, 2024Lions 20-13

Lions vs Cardinals line movement

MONEYLINE Lions to win at Pinnacle

Market (latest pregame line)

Spread (ARI)

+5.5

Total

55.5

Moneyline

DET
-258
ARI
+210

Line movement, tracked by Agatha since first sighting (16 snapshots)

  • Moneyline (ARI) at FanDuel: opened +205, now +190
  • Spread (ARI) at FanDuel: opened +5.5, now +5.5
  • Total at FanDuel: opened 51.5, now 54.5

Agatha's pick for Lions vs Cardinals

The Lions. Agatha gave Detroit a 66% chance to win at State Farm Stadium, Glendale. It was one of Agatha's Best NFL Bets for Oct 11.

TV: Fox

Best Bets on this game

  1. nflFINAL
    Isaac TeSlaa Under 2.5 receptions
    Detroit Lions at Arizona Cardinals - 4:25 PM ET
    60%
    WONLEAN1U
    WON
    SEALED ODDS-172DraftKings

Up next

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  2. Sun, Nov 15, 4:05 PM ETLos Angeles Rams vs Arizona CardinalsAgatha's call: Los Angeles Rams to win, 72%
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  5. Sun, Nov 15, 1:00 PM ETMinnesota Vikings vs Green Bay PackersAgatha's call: Green Bay Packers to win, 60%