ATL @ HOUFinal 6-2, Sep 18, 2026
IP 2.0, H 2, R 2, ER 2, BB 0, K 3, HR 1, PC-ST 30-23, ERA 4.79, PC 30
Betting: HOU moneyline lost, run line +1.5 did not cover
BaseballMLBHouston AstrosRelief pitcher
Enyel De Los Santos
Stats, career and game logEnyel De Los Santos is a relief pitcher for the Houston Astros who pitched an immaculate inning on September 27, 2022.
363 MLB games390 strikeouts
Updated
About Enyel De Los Santos
Enyel De Los Santos is a relief pitcher for the Houston Astros, born on December 25, 1995, in San Pedro de Macoris in the Dominican Republic. He bats and throws right-handed, and he made his MLB debut on Jul 10, 2018, with the Philadelphia Phillies.
In the 2024 regular season, Santos pitched in 64 games for the San Diego Padres, the New York Yankees and the Chicago White Sox, with a 5.20 ERA and 66 strikeouts in 64.0 innings. Through the 2025 season, he had a 4.44 ERA and 323 strikeouts in 314.1 innings over 294 games.
Agatha Research DeskUpdated Nov 2, 2026Season by season363
363 appearances: 360 regular season, 3 postseason. Every MLB appearance of his career, newest season first.
| Season | Team | Games | Starts | IP | K | BB | ERA | WHIP |
|---|---|---|---|---|---|---|---|---|
| 2026 | HOU | 66 | 0 | 71.1 | 67 | 20 | 4.79 | 1.25 |
| 2025 | ATL, HOU | 65 | 0 | 66.0 | 62 | 24 | 4.36 | 1.29 |
| 2024 | SD, NYY, CHW | 64 | 0 | 64.0 | 66 | 25 | 5.20 | 1.41 |
| 2023 |  CLE | 70 | 0 | 65.2 | 62 | 25 | 3.29 | 1.14 |
| 2022 | CLE | 50 | 0 | 53.1 | 61 | 17 | 3.04 | 1.07 |
| 2022 postseason | 3 | 0 | 3.1 | 1 | 1 | 0.00 | 0.90 | |
| 2021 | PHI, PIT | 33 | 0 | 35.1 | 48 | 18 | 6.37 | 1.73 |
| 2019 |  PHI | 5 | 1 | 11.0 | 9 | 5 | 7.36 | 1.64 |
| 2018 | PHI | 7 | 2 | 19.0 | 15 | 8 | 4.74 | 1.42 |
| Career | 360 | 3 | 385.2 | 390 | 142 | 4.50 | 1.30 | |
| Career postseason | 3 | 0 | 3.1 | 1 | 1 | 0.00 | 0.90 |
How he is doing now
2026 pitching4.79 ERA71.1 innings, 67 strikeouts, 1.25 WHIP
Astros81-812026 regular season, 0-2 in the playoffs
Last game2.0 IP, 3 K, 2 ERSep 18 vs Braves
Injury status
No active flag. Latest report Out (40d ago), no longer on the injury report.
Game log, 2026
KC @ HOUFinal 5-2, Sep 16, 2026
IP 1.1, H 2, R 3, ER 2, BB 2, K 2, HR 1, PC-ST 28-15, ERA 4.67, PC 28
Betting: HOU moneyline lost, run line -1.5 did not cover
HOU @ TBFinal 4-14, Sep 13, 2026
IP 0.2, H 4, R 2, ER 2, BB 0, K 0, HR 1, PC-ST 24-14, ERA 4.50, PC 24
Betting: HOU moneyline lost, run line +1.5 did not cover
HOU @ PHIFinal 7-11, Sep 9, 2026
IP 0.2, H 0, R 0, ER 0, BB 0, K 1, HR 0, PC-ST 7-5, ERA 4.28, PC 7
Betting: HOU moneyline lost, run line +1.5 did not cover
Show all 10 games
ARI @ HOUFinal 4-3, Sep 5, 2026
IP 1.2, H 0, R 0, ER 0, BB 0, K 2, HR 0, PC-ST 22-17, ERA 4.32, PC 22
Betting: HOU moneyline lost, run line +1.5 covered
ARI @ HOUFinal 1-3, Sep 4, 2026
IP 0.1, H 1, R 0, ER 0, BB 1, K 0, HR 0, PC-ST 9-4, ERA 4.43, PC 9
Betting: HOU moneyline won, run line -1.5 covered
CHW @ HOUFinal 3-6, Aug 31, 2026
IP 1.0, H 0, R 0, ER 0, BB 3, K 0, HR 0, PC-ST 27-14, ERA 4.45, PC 27
Betting: HOU moneyline won, run line -1.5 covered
HOU @ NYMFinal 2-6, Aug 29, 2026
IP 2.0, H 1, R 0, ER 0, BB 0, K 2, HR 0, PC-ST 20-13, ERA 4.52, PC 20
Betting: HOU moneyline lost, run line +1.5 did not cover
HOU @ NYYFinal 3-9, Aug 26, 2026
IP 1.2, H 1, R 2, ER 2, BB 1, K 3, HR 1, PC-ST 28-16, ERA 4.67, PC 28
Betting: HOU moneyline lost, run line +1.5 did not cover
ATH @ HOUFinal 7-6, Aug 23, 2026
IP 0.1, H 3, R 3, ER 3, BB 0, K 1, HR 0, PC-ST 25-16, ERA 4.50, PC 25
Betting: HOU moneyline lost, run line -1.5 did not cover
Box score lines from ESPN.
Betting: his team's result at the closing moneyline and run line most of our sportsbooks closed at (3 books or more).
Did you know?!
First ever 2-pitch inning
On August 16, 2025, Santos pitched the first ever 2-pitch inning.
Career
8years2018 to 2026
- 2018MLB debutPhiladelphia Phillies
- 2026Best season71.1 IP, 67 K, 4.79 ERA in 66 games
- Sep 18, 2026Latest game2.0 IP, 3 K, 2 ER vs Braves
Regular season
360 games
385.2 IP, 390 K, 4.50 ERA
Postseason
3 games
3.1 IP, 1 K, 0.00 ERA
Honors
- Pitched an immaculate inning on September 27, 2022
- Pitched the first ever 2-pitch inning on August 16, 2025
MLB debut
2018 seasonPhiladelphia Phillies
Latest game
Sep 18, 2026: 2.0 IP, 3 K, 2 ERBraves 6, Astros 2
Most often against
The teams he has faced most, with his teams' record and his line against each.
Los Angeles Angels17 games
7-10his teams
His line: 18.0 IP, 15 K, 3.50 ERA
Last met Aug 18, 2026
Texas Rangers16 games
9-7his teams
His line: 13.2 IP, 13 K, 5.27 ERA
Last met Aug 1, 2026
Baltimore Orioles15 games
7-8his teams
His line: 15.2 IP, 17 K, 1.72 ERA
Last met Jul 18, 2026
Detroit Tigers15 games
7-8his teams
His line: 13.2 IP, 14 K, 3.95 ERA
Last met Jun 28, 2026
Arizona Diamondbacks11 games
5-6his teams
His line: 12.1 IP, 9 K, 4.38 ERA
Last met Sep 5, 2026
Athletics11 games
8-3his teams
His line: 13.2 IP, 13 K, 5.27 ERA
Last met Aug 23, 2026
Injury history
ESPN's injury reports, newest first.
- Oct 2, 2026Out Knee
The Astros placed De Los Santos on the 15-day injured list Saturday with right knee tendinitis, Matt Kawahara of the Houston Chronicle reports.
ESPN / HOU
- Sep 19, 202615-Day-IL Knee
De Los Santos secured the save Thursday against the Tigers, allowing one run on two hits and no walks in the ninth inning. He did not record a strikeout.
ESPN / HOU
Sources and updates
Stats, scores and injury reports come from Agatha's own records: the SABR Lahman Baseball Database for the seasons through 2025, MLB's own box scores, its transactions and ESPN's injury reports.
Updated Nov 11, 2026, 7:24 AM ET. Results and form refresh after every game; biography facts are checked weekly.