| Florida at Texas | Florida 27, Texas 24 | ABC |
| Ohio State at Indiana | Ohio State 19, Indiana 15 | Fox |
| Mississippi State at LSU | Mississippi State 0, LSU 31 | ESPN, Disney+ |
| Virginia at SMU | Virginia 13, SMU 23 | CW |
| Cincinnati at West Virginia | Cincinnati 42, West Virginia 45 | TNT |
| Kansas at Kansas State | Kansas 24, Kansas State 35 | FS1 |
| Charleston Southern at Clemson | Charleston Southern 0, Clemson 37 | ACC Network |
| Pittsburgh at Boston College | Pittsburgh 21, Boston College 27 | ESPN2 |
| Northwestern at Michigan State | Northwestern 24, Michigan State 21 | Peacock |
| Ball State at Bowling Green | Ball State 32, Bowling Green 31 | ESPN+ |
| Georgia State at James Madison | Georgia State 22, James Madison 49 | ESPNU |
| Florida Atlantic at Army | Florida Atlantic 24, Army 56 | CBSSN |
| Rutgers at Maryland | Rutgers 37, Maryland 30 | BTN |
| Charlotte at Temple | Charlotte 38, Temple 31 | ESPN+ |
| Massachusetts at Buffalo | Massachusetts 18, Buffalo 25 | ESPN+ |
| The Citadel at Texas A&M | The Citadel 0, Texas A&M 41 | SECN+ |
| Western Michigan at Central Michigan | Western Michigan 21, Central Michigan 14 | ESPN+ |
| Auburn at Georgia | Auburn 27, Georgia 24 | ESPN |
| Alabama at Tennessee | Alabama 10, Tennessee 26 | ABC |
| Missouri at Ole Miss | Missouri 3, Ole Miss 31 | SEC Network |
| Arizona State at Texas Tech | Arizona State 25, Texas Tech 53 | Fox |
| Georgia Tech at Virginia Tech | Georgia Tech 24, Virginia Tech 34 | ACC Network |
| North Carolina at Duke | North Carolina 24, Duke 20 | ESPN2 |
| Penn State at Michigan | Penn State 18, Michigan 21 | CBS |
| Toledo at Eastern Michigan | Toledo 34, Eastern Michigan 14 | ESPN+ |
| Akron at Miami (OH) | Akron 14, Miami (OH) 34 | ESPN+ |
| Northern Illinois at Wyoming | Northern Illinois 23, Wyoming 41 | CW |
| UNLV at Air Force | UNLV 31, Air Force 41 | CBSSN |
| Tulsa at Rice | Tulsa 38, Rice 17 | ESPN+ |
| Troy at Louisiana | Troy 6, Louisiana 33 | ESPN+ |
| Washington State at Oregon State | Washington State 30, Oregon State 48 | USA Net |
| Florida State at Miami | Florida State 35, Miami 43 | ESPN, Disney+ |
| Arkansas at Vanderbilt | Arkansas 31, Vanderbilt 21 | ESPN2 |
| TCU at Baylor | TCU 17, Baylor 6 | FS1 |
| Kent State at South Florida | Kent State 2, South Florida 29 | ESPN+ |
| Arkansas State at Southern Miss | Arkansas State 23, Southern Miss 13 | ESPN+ |
| Nevada at North Dakota State | Nevada 17, North Dakota State 31 | CBSSN |
| Notre Dame at BYU | Notre Dame 24, BYU 28 | ABC |
| Oklahoma State at Houston | Oklahoma State 32, Houston 35 | Fox |
| Wisconsin at UCLA | Wisconsin 7, UCLA 17 | NBC |
| Kentucky at Oklahoma | Kentucky 21, Oklahoma 13 | SEC Network |
| Louisville at Syracuse | Louisville 34, Syracuse 26 | ACC Network |
| Elon at Stanford | Elon 7, Stanford 34 | ACCNX |
| Navy at UTSA | Navy 34, UTSA 38 | ESPNU |
| Louisiana Tech at UL Monroe | Louisiana Tech 24, UL Monroe 0 | ESPN+ |
| San Jose State at UTEP | San Jose State 24, UTEP 11 | MW+ |
| Ohio at Sacramento State | Ohio 48, Sacramento State 7 | ESPN+ |
| Utah at Colorado | Utah 27, Colorado 24 | ESPN |
| Wake Forest at California | Wake Forest 41, California 7 | ESPN2 |
| New Mexico at Hawai'i | New Mexico 21, Hawai'i 10 | FS1 |
| Fresno State at San Diego State | Fresno State 23, San Diego State 26 | CBSSN |
| Nebraska at Oregon | Nebraska 14, Oregon 17 | Fox |