| Indiana at Nebraska | Indiana 20, Nebraska 17 | Fox |
| Texas A&M at Missouri | Texas A&M 6, Missouri 27 | ABC, Disney+ |
| Arizona at West Virginia | Arizona 52, West Virginia 31 | TNT |
| UCF at Oklahoma State | UCF 28, Oklahoma State 42 | ESPN2 |
| North Carolina at Pittsburgh | North Carolina 21, Pittsburgh 17 | ESPN |
| Wake Forest at NC State | Wake Forest 38, NC State 14 | CW |
| Sacramento State at Bowling Green | Sacramento State 10, Bowling Green 38 | ESPN+ |
| Tulane at Army | Tulane 17, Army 20 | CBSSN |
| Ball State at Northwestern | Ball State 14, Northwestern 45 | BTN |
| South Carolina at Florida | South Carolina 38, Florida 19 | SEC Network |
| Rice at East Carolina | Rice 12, East Carolina 28 | ESPN+ |
| Old Dominion at App State | Old Dominion 10, App State 3 | ESPN+ |
| Miami (OH) at Massachusetts | Miami (OH) 20, Massachusetts 19 | ESPN+ |
| Ole Miss at Vanderbilt | Ole Miss 52, Vanderbilt 17 | ESPN, Disney+ |
| UCLA at Oregon | UCLA 17, Oregon 15 | CBS |
| Houston at Kansas State | Houston 35, Kansas State 16 | Fox |
| Duke at Georgia Tech | Duke 25, Georgia Tech 28 | ESPN2 |
| Virginia Tech at California | Virginia Tech 20, California 25 | ACC Network |
| Illinois at Michigan State | Illinois 38, Michigan State 37 | FS1 |
| Charlotte at North Texas | Charlotte 10, North Texas 50 | ESPN+ |
| Buffalo at Toledo | Buffalo 23, Toledo 8 | ESPN+ |
| Central Michigan at Ohio | Central Michigan 14, Ohio 31 | ESPN+ |
| Kent State at Western Michigan | Kent State 7, Western Michigan 38 | ESPN+ |
| Texas vs Oklahoma (in Dallas) | Texas 24, Oklahoma 27 | ABC |
| Stanford at Notre Dame | Stanford 7, Notre Dame 58 | NBC |
| Tulsa at Navy | Tulsa 26, Navy 34 | CBSSN |
| Eastern Michigan at Akron | Eastern Michigan 25, Akron 23 | ESPN+ |
| UConn at Temple | UConn 34, Temple 20 | ESPNU |
| Maryland at Ohio State | Maryland 16, Ohio State 45 | BTN |
| Tennessee at Arkansas | Tennessee 24, Arkansas 17 | SEC Network |
| San Diego State at Oregon State | San Diego State 14, Oregon State 66 | USA Net |
| LSU at Kentucky | LSU 34, Kentucky 35 | ESPN |
| UAB at Memphis | UAB 13, Memphis 38 | ESPN2 |
| Nevada at UTEP | Nevada 30, UTEP 13 | FS1 |
| Coastal Carolina at Marshall | Coastal Carolina 27, Marshall 21 | ESPN+ |
| North Dakota State at UNLV | North Dakota State 7, UNLV 13 | CW |
| Georgia at Alabama | Georgia 20, Alabama 17 | ABC |
| USC at Penn State | USC 31, Penn State 23 | NBC |
| Syracuse at Virginia | Syracuse 25, Virginia 28 | ACC Network |
| Louisiana at Louisiana Tech | Louisiana 31, Louisiana Tech 32 | ESPN+ |
| Air Force at Northern Illinois | Air Force 28, Northern Illinois 7 | CBSSN |
| Kansas at Utah | Kansas 24, Utah 41 | ESPN |
| Minnesota at Purdue | Minnesota 13, Purdue 41 | BTN |
| James Madison at Georgia Southern | James Madison 27, Georgia Southern 24 | ESPNU |
| Hawai'i at Arizona State | Hawai'i 12, Arizona State 30 | FS1 |
| Boise State at Fresno State | Boise State 38, Fresno State 31 | CW |