| Arizona at Texas Tech | Arizona 26, Texas Tech 34 | ESPN |
| Wisconsin at Iowa | Wisconsin 0, Iowa 30 | Fox |
| SMU at Syracuse | SMU 27, Syracuse 30 | ESPN2 |
| California at NC State | California 10, NC State 31 | ACC Network |
| Boston College at Duke | Boston College 2, Duke 47 | CW |
| Illinois at Maryland | Illinois 20, Maryland 17 | FS1 |
| UAB at South Florida | UAB 10, South Florida 30 | ESPNU |
| Notre Dame vs Navy (in Foxborough) | Notre Dame 35, Navy 13 | ABC |
| Bowling Green at Western Michigan | Bowling Green 10, Western Michigan 23 | CBSSN |
| Michigan at Rutgers | Michigan 28, Rutgers 21 | BTN |
| Auburn at Ole Miss | Auburn 15, Ole Miss 45 | SEC Network |
| Marshall at Old Dominion | Marshall 36, Old Dominion 23 | ESPN+ |
| Kansas State at Colorado | Kansas State 24, Colorado 27 | TNT |
| Coastal Carolina at Georgia State | Coastal Carolina 31, Georgia State 20 | ESPN+ |
| Temple at East Carolina | Temple 9, East Carolina 17 | ESPN+ |
| Louisiana Tech at South Alabama | Louisiana Tech 35, South Alabama 20 | ESPN+ |
| UConn at Air Force | UConn 26, Air Force 35 | MW+ |
| Stanford at Louisville | Stanford 24, Louisville 52 | ACC Network |
| Minnesota at Indiana | Minnesota 16, Indiana 23 | CBS |
| Arizona State at BYU | Arizona State 20, BYU 27 | Fox |
| Northwestern at Oregon | Northwestern 26, Oregon 34 | Peacock |
| Kansas at TCU | Kansas 16, TCU 22 | FS1 |
| Southern Miss at UL Monroe | Southern Miss 35, UL Monroe 21 | ESPN+ |
| Florida vs Georgia (in Atlanta) | Florida 8, Georgia 27 | ABC, Disney+ |
| Colorado State at Utah State | Colorado State 14, Utah State 31 | USA Net |
| UTEP at North Dakota State | UTEP 7, North Dakota State 31 | MW+ |
| Florida International at Liberty | Florida International 10, Liberty 49 | CBSSN |
| Utah at Cincinnati | Utah 49, Cincinnati 25 | ESPN |
| Virginia at Wake Forest | Virginia 7, Wake Forest 51 | ESPN2 |
| New Mexico at San Jose State | New Mexico 21, San Jose State 16 | MW+ |
| Nevada at UCLA | Nevada 0, UCLA 27 | BTN |
| South Carolina at Oklahoma | South Carolina 42, Oklahoma 25 | SEC Network |
| Purdue at Penn State | Purdue 17, Penn State 31 | BTN |
| App State at Georgia Southern | App State 3, Georgia Southern 19 | ESPN+ |
| Oklahoma State at Iowa State | Oklahoma State 49, Iowa State 51 | Fox |
| Clemson at Florida State | Clemson 36, Florida State 24 | ACC Network |
| Washington State at San Diego State | Washington State 20, San Diego State 26 | CBSSN |
| Mississippi State at Texas | Mississippi State 3, Texas 31 | ESPN, Disney+ |
| Miami at North Carolina | Miami 38, North Carolina 35 | ABC |
| Ohio State at USC | Ohio State 18, USC 30 | NBC |
| Georgia Tech at Pittsburgh | Georgia Tech 11, Pittsburgh 34 | ESPN2 |
| Missouri at Arkansas | Missouri 34, Arkansas 10 | SEC Network |
| Washington at Nebraska | Washington 17, Nebraska 10 | BTN |
| Army at Memphis | Army 22, Memphis 49 | ESPNU |
| Texas State at Boise State | Texas State 45, Boise State 46 | CW |
| Northern Illinois at UNLV | Northern Illinois 24, UNLV 31 | CBSSN |
| Oregon State at Fresno State | Oregon State 22, Fresno State 38 | USA Net |