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49ers vs Seahawks Prediction

Sunday, Oct 11, 2026, 4:25 PM ET, Lumen Field, Seattle, Week 5

Agatha Research Desk, Updated

San Francisco 49ersAWAYSan Francisco49ers

FINAL

3229

AGATHA'S PICKSeattle SeahawksHOMESeattleSeahawks
63%WIN CHANCESeahawks to WinLOST#819 SEALED

Win chance at the seal 63%

Agatha's pick: Seahawks to WinTHE VERDICT

Final score: 49ers 32, Seahawks 29

SEALED ODDS
-159Stake
CLOSING ODDS
Same as sealedat the start
STAKE
1 unitflat, every pick
RESULT
LOST -1.00uat the sealed price
GRADED
7:45 PM ETreceipt #819

Game Center

Team1234T
SF71401132
SEA7613329

Play-by-play

  • [4- 0:47] B.Purdy kneels to SF 40 for -1 yards.

Leaders

  • Sam Darnold (SEA): 18/29, 195 YDS, 1 TD, 2 INT
  • Emanuel Wilson (SEA): 20 CAR, 61 YDS, 1 TD
  • Jaxon Smith-Njigba (SEA): 5 REC, 102 YDS, 1 TD
  • Brock Purdy (SF): 19/29, 189 YDS, 2 TD, 1 INT
  • Christian McCaffrey (SF): 11 CAR, 68 YDS, 1 TD
  • Mike Evans (SF): 7 REC, 113 YDS, 1 TD

Game-day injuries

  • Drake Thomas (SEA) - Questionable
  • Jalen Milroe (SEA) - Out
  • Chazz Surratt (SEA) - Out
  • Robert Henry Jr. (SEA) - Out
  • Nick Kallerup (SEA) - Out
  • Deebo Samuel Sr. (SF) - Out
  • Kurtis Rourke (SF) - Out
  • Marques Sigle (SF) - Out
  • James Thompson Jr. (SF) - Out
  • Kyle Juszczyk (SF) - Out
SF

Tale of the tape

SEA

49ers vs Seahawks recent form

SF 4-1 49ers: last 5 games

  1. W24-14DEN Oct 4 Denver Broncos, 24-14
  2. W36-30ARI Sep 27 Arizona Cardinals, 36-30
  3. W35-13MIA Sep 20 Miami Dolphins, 35-13
  4. W27-7LAR Sep 10 Los Angeles Rams, 27-7
  5. L6-41SEA Jan 17 Seattle Seahawks, 6-41

SEA 4-1 Seahawks: last 5 games

  1. W30-23LAC Oct 4 Los Angeles Chargers, 30-23
  2. L31-33WSH Sep 27 Washington Commanders, 31-33
  3. W31-7ARI Sep 20 Arizona Cardinals, 31-7
  4. W13-10NE Sep 9 New England Patriots, 13-10
  5. W29-13NE Feb 8 New England Patriots, 29-13
Points scored, last 5SF 128SEA 134
Points allowed, last 5fewer is betterSF 105SEA 86

49ers vs Seahawks head-to-head

Since Nov 23, 2023: 49ers 4, Seahawks 3

  1. Jan 17, 2026Seahawks 41-6
  2. Jan 3, 2026Seahawks 13-3
  3. Sep 7, 202549ers 17-13
  4. Nov 17, 2024Seahawks 20-17
  5. Oct 10, 202449ers 36-24
  6. Dec 10, 202349ers 28-16
  7. Nov 23, 202349ers 31-13

49ers vs Seahawks line movement

MONEYLINE Seahawks to win at BetOnline

Market (latest pregame line)

Spread (SEA)

-3

Total

46.5

Moneyline

SF
+138
SEA
-160

Line movement, tracked by Agatha since first sighting (13 snapshots)

  • Moneyline (SEA) at FanDuel: opened -200, now -164
  • Spread (SEA) at FanDuel: opened -3.5, now -3
  • Total at FanDuel: opened 47.5, now 46.5

Agatha's pick for 49ers vs Seahawks

The Seahawks. Agatha gave Seattle a 63% chance to win at Lumen Field, Seattle. It was one of Agatha's Best NFL Bets for Oct 11.

TV: Fox

Best Bets on this game

  1. nflFINAL
    Tory Horton Under 1.5 receptions
    San Francisco 49ers at Seattle Seahawks - 4:25 PM ET
    60%
    WONLEAN1U
    WON
    SEALED ODDS-198DraftKings

Up next

  1. Sun, Nov 15, 4:25 PM ETSan Francisco 49ers vs Dallas CowboysAgatha's call: San Francisco 49ers to win, 64%
  2. Sun, Nov 15, 4:05 PM ETSeattle Seahawks vs Las Vegas RaidersAgatha's call: Seattle Seahawks to win, 73%
  3. Sun, Nov 15, 9:30 AM ETNew England Patriots vs Detroit LionsAgatha's call: Detroit Lions to win, 56%
  4. Sun, Nov 15, 1:00 PM ETKansas City Chiefs vs Atlanta FalconsAgatha's call: Kansas City Chiefs to win, 65%
  5. Sun, Nov 15, 1:00 PM ETHouston Texans vs Cleveland BrownsAgatha's call: Houston Texans to win, 61%