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Chiefs vs Bills Odds

Thursday, Nov 26, 2026, 8:20 PM ET, Highmark Stadium, Orchard Park, Week 12

Agatha Research Desk

TV: NBC

Agatha is watching this one

Agatha has no pick on this game.

Agatha prices NFL games from eight days before the start, so her call on this game can post from Wed, Nov 18 (ET).

Market (latest pregame line)

Spread (BUF)

-2.5

Total

50.5

Line movement, tracked by Agatha since first sighting (1 snapshot)

  • Spread (BUF) at DraftKings: opened -2.5, now -2.5
  • Total at DraftKings: opened 50.5, now 50.5

Chiefs vs Bills injury report

Kansas City Chiefs

Buffalo Bills

Chiefs vs Bills recent form

Chiefs: last 5 games

Last 5: 3-2

  1. Nov 8vs New York JetsW35-12
  2. Nov 1at Denver BroncosL24-28
  3. Oct 25at Seattle SeahawksL3-20
  4. Oct 18vs Los Angeles ChargersW22-6
  5. Oct 4at Las Vegas RaidersW30-27

Bills: last 5 games

Last 5: 4-1

  1. Nov 9at Minnesota VikingsW23-6
  2. Nov 1vs Baltimore RavensW36-10
  3. Oct 18at Las Vegas RaidersW33-30
  4. Oct 12at Los Angeles RamsW37-34
  5. Oct 4vs New England PatriotsL26-29

Chiefs vs Bills head-to-head

Since Dec 10, 2023: Bills 3, Chiefs 2

  1. Nov 2, 2025Bills 28-21
  2. Jan 26, 2025Chiefs 32-29
  3. Nov 17, 2024Bills 30-21
  4. Jan 21, 2024Chiefs 27-24
  5. Dec 10, 2023Bills 20-17

Chiefs vs Bills key players

Kansas City Chiefs

Buffalo Bills